Composition:
Lukast 4 mg Granules : Each chewable tablet contains 4.16 mg montelukast sodium, equivalent to 4 mg of montelukast.
Mechanism of action:
The Cysteinyl leukotrines (LTC4, LTD4, and LTE4) are products of arachidonic acid metabolism and released from various cells, including mast cells and eosinophils. CysL.Ts have been correlated with the pathophysiology of asthma and allergic rhinitis. Montelukast binds with high affinity and selectivity to the CysL.T1 receptor in preference to other pharmacologically important airway receptors. Montelukast inhibits physiologic actions of LTD4 at the CysL.T1 receptor without any agonist activity.
Indications:
Contraindications:
Hypersensitivity to any component of this product
Dosage and administrations:
Asthma:
Montelukast should be taken once daily in the evening. The following doses are recommended:
Allergic Rhinitis: the dose should be taken once daily (in the evening or in the morning)
The following doses for the treatment of symptoms of seasonal allergic rhinitis are recommended:
The following doses for the treatment of symptoms of perennial allergic rhinitis are recommended:
For pediatric patients 2 to 5 years of age: one 4-mg chewable tablet or one packet of 4-mg (oral granules).
For pediatric patients 6 to 23 months of age: one packet of 4-mg oral granules.
How supplied:
Lukast 4 mg Granules: Pack of 7 or 20 or 28 sachets.