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Home by Therapeutic Group Respiratory drugs

ZETRIZIN PLUS

Zetrizin plus

Product Information

CHEMICAL COMPOSITION:

Each film coated tablet contains:

Cetirizine dihydrochloride       5 mg

Phenylephrine hydrochloride 10 mg

Paracetamol                          325 mg

 

  • Pharmacotherapeutic group for Cetirizine:

Cetirizine: Piperazine derivatives.

Cetirizine, a human metabolite of hydroxyzine, is a potent and selective antagonist of peripheral H1-receptors.

In addition to its anti-H1 effect, cetirizine was shown to display anti-allergic activities: at a dose of 10 mg once or twice daily, it inhibits the late phase recruitment of eosinophils, in the skin and conjunctiva of atopic subjects submitted to allergen challenge.

 

  • Pharmacotherapeutic group for Phenylephrine:

Phenylephrine is a sympathomimetic agent with mainly direct effects on adrenergic receptors. It has predominantly alpha adrenergic activity and is without stimulating effects on the central nervous system. The sympathomimetic effect of phenylephrine produces vasoconstriction which in turn relieves nasal congestion.

 

  • Pharmacotherapeutic group for Paracetamol:

Analgesic: The mechanism of analgesic action has not been fully determined. Paracetamol may act predominantly by inhibiting prostaglandin synthesis in the central nervous system (CNS) and to a lesser extent, through a peripheral action by blocking pain-impulse generation. The peripheral action may also be due to inhibition of prostaglandin synthesis or to inhibition of the synthesis or actions of other substances that sensitize pain receptors to mechanical or chemical stimulation.

Antipyretic: Paracetamol probably produces antipyretic by acting centrally on the hypothalamic heat-regulation center to produce peripheral vasodilation resulting in increased blood flow through the skin, sweating and heat loss. The central action probably involves inhibition of prostaglandin synthesis in the hypothalamus.

 

INDICATIONS

Zetrizin – Plus is indicated for the symptomatic treatment of allergic rhinitis, fever and nasal congestion.

 

DOSAGE AND ADMINISTRATION

Adults and children (12 years and above): One tablet twice daily or as recommended by the physician.The recommended dosage should not be exceeded.

 

Packaging:

Zetrizin- Plus: Pack of 20 Film coated tablets.

Categories: Respiratory drugs, Tablets
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