Furosemide ALFARES 20: Each tablet contains: 20 mg Furosemide ALFARES
Furosemide ALFARES 40: Each tablet contains: 40 mg Furosemide ALFARES
Mechanism of action:
It has been demonstrated that FUROSEMIDE ALFARES inhibits primarily the absorption of sodium and chloride not only in the proximal and distal tubules but also in the loop of Henle. The high degree of efficacy is largely due to the unique site of action. The action on the distal tubule is independent of any inhibitory effect on carbonic anhydrase and aldosterone.
Indications:
Edema: FUROSEMIDE ALFARES is indicated in adults and pediatric patients for the treatment of edema associated with congestive heart failure, cirrhosis of the liver and renal disease, including the nephrotic syndrome. FUROSEMIDE ALFARES is particularly useful when an agent with greater diuretic potential is desired.
Hypertension: Oral FUROSEMIDE ALFARES may be used in adults for the treatment of hypertension alone or in combination with other antihypertensive agents. Hypertensive patients who cannot be adequately controlled with thiazides will probably also not be adequately controlled with FUROSEMIDE ALFARES alone.
Dosage and administration:
Adults: The usual initial dose of FUROSEMIDE ALFARES is 20 to 80 mg given as a single dose. Ordinarily a prompt diuresis ensues. If needed, the same dose can be administered 6 to 8 hours later or the dose may be increased. The dose of FUROSEMIDE ALFARES may be carefully titrated up to 600 mg/day in patients with clinically severe edematous states. Edema may be most efficiently and safely mobilized by giving FUROSEMIDE ALFARES on 2 to 4 consecutive days each week. When doses exceeding 80 mg/day are given for prolonged periods, careful clinical observation and laboratory monitoring are particularly advisable.
Geriatric patients: In general, dose selection for the elderly patient should be cautious, usually starting at the low end of the dosing range.
Pediatric patients: The usual initial dose of oral FUROSEMIDE ALFARES in pediatric patients is 2 mg/kg body weight, given as a single dose. If the diuretic response is not satisfactory after the initial dose, dosage may be increased by 1 or 2 mg/kg no sooner than 6 to 8 hours after the previous dose. Doses greater than 6 mg/kg body weight are not recommended. For maintenance therapy in pediatric patients, the dose should be adjusted to the minimum effective level.
Adults: The usual initial dose of FUROSEMIDE ALFARES for hypertension is 80 mg, usually divided into 40 mg twice a day. Dosage should then be adjusted according to response. If response is not satisfactory, add other anti-hypertensive agents. Changes in blood pressure must be carefully monitored when FUROSEMIDE ALFARES is used with other antihypertensive drugs, especially during initial therapy. To prevent excessive drop in blood pressure, the dosage of other agents should be reduced by at least 50 percent when FUROSEMIDE ALFARES is added to the regimen. As the blood pressure falls under the potentiating effect of FUROSEMIDE ALFARES, a further reduction in dosage or even discontinuation of other antihypertensive drugs may be necessary.
Geriatric patients: In general, dose selection and dose adjustment for the elderly patient should be cautious, usually starting at the low end of the dosing range.
Packaging: